InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ripk3

Summary

InnateDB Protein

IDBP-165976.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ripk3

Protein Name

receptor-interacting serine-threonine kinase 3

Synonyms

2610528K09Rik; AW107945; Rip3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022830

InnateDB Gene

IDBG-165974 (Ripk3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	103 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0032403	protein complex binding
GO:0042802	identical protein binding

Biological Process

GO:0001914	regulation of T cell mediated cytotoxicity
GO:0002819	regulation of adaptive immune response
GO:0006468	protein phosphorylation
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0010922	positive regulation of phosphatase activity
GO:0016032	viral process
GO:0032147	activation of protein kinase activity
GO:0032649	regulation of interferon-gamma production
GO:0033077	T cell differentiation in thymus
GO:0038061	NIK/NF-kappaB signaling
GO:0043029	T cell homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0046006	regulation of activated T cell proliferation
GO:0046777	protein autophosphorylation
GO:0048535	lymph node development
GO:0048536	spleen development
GO:0048538	thymus development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0051347	positive regulation of transferase activity
GO:0051351	positive regulation of ligase activity
GO:0051353	positive regulation of oxidoreductase activity
GO:0060545	positive regulation of necroptotic process
GO:0070235	regulation of activation-induced cell death of T cells
GO:0070266	necroptotic process
GO:0090312	positive regulation of protein deacetylation
GO:1990000	amyloid fibril formation
GO:2000377	regulation of reactive oxygen species metabolic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2000452	regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0097342	ripoptosome

Protein Structure and Domains

PDB ID

MGI:2154952

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt