InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Igfbp2

Summary

InnateDB Protein

IDBP-166045.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igfbp2

Protein Name

insulin-like growth factor binding protein 2

Synonyms

AI255832; IBP-2; Igfbp-2; mIGFBP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046610

InnateDB Gene

IDBG-166043 (Igfbp2)

Protein Structure

UniProt Annotation

Function

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary. {ECO:0000269PubMed:7529732}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0031994	insulin-like growth factor I binding
GO:0031995	insulin-like growth factor II binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007165	signal transduction
GO:0007565	female pregnancy
GO:0007568	aging
GO:0007584	response to nutrient
GO:0009612	response to mechanical stimulus
GO:0010226	response to lithium ion
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032870	cellular response to hormone stimulus
GO:0042104	positive regulation of activated T cell proliferation
GO:0042493	response to drug
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
GO:0043627	response to estrogen
GO:0048545	response to steroid hormone
GO:0051384	response to glucocorticoid

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0016324	apical plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96437

InterPro

IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR012210 Insulin-like growth factor binding protein 2
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata

PFAM

PF00086
PF00219

PRINTS

PR01978
PR01976

PIRSF

SMART

SM00211
SM00121

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt