InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ggn

Summary

InnateDB Protein

IDBP-166228.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ggn

Protein Name

gametogenetin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033886

InnateDB Gene

IDBG-166224 (Ggn)

Protein Structure

UniProt Annotation

Function

May be involved in spermatogenesis. {ECO:0000269PubMed:12574169}.

Subcellular Localization

Isoform 1: Cytoplasm, perinuclear region. Note=Localizes along the nuclear membrane.Isoform 2: Cytoplasmic vesicle.Isoform 3: Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Testis-specific. Specifically expressed in the germ cells and not in the somatic, Sertoli, or Leydig cells. In adult testis, expression starts in stage VIII pachytene spermatocytes, increases in stage IX and X pachytene spermatocytes, and culminates in stage XI diplotene spermatocytes and the meiotic cells in stage XII. Expression decreases slightly in step 1-3 spermatids, further decreases in step 4-11 spermatids, and is no longer detectable in step 12 spermatids and beyond. Isoform 2 is mainly expressed in testis. {ECO:0000269PubMed:12574169}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006461	protein complex assembly
GO:0007275	multicellular organismal development
GO:0007276	gamete generation
GO:0007283	spermatogenesis
GO:0008104	protein localization
GO:0030154	cell differentiation

Cellular Component

GO:0005635	nuclear envelope
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0048471	perinuclear region of cytoplasm