InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dennd1a

Summary

InnateDB Protein

IDBP-166361.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dennd1a

Protein Name

DENN/MADD domain containing 1A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099848

InnateDB Gene

IDBG-166357 (Dennd1a)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles. {ECO:0000269PubMed:17182770}.

Subcellular Localization

Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269PubMed:17182770}; Peripheral membrane protein {ECO:0000269PubMed:17182770}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:17182770}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017112	Rab guanyl-nucleotide exchange factor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006897	endocytosis
GO:0015031	protein transport
GO:0032313	regulation of Rab GTPase activity
GO:0032483	regulation of Rab protein signal transduction
GO:0032851	positive regulation of Rab GTPase activity
GO:0048488	synaptic vesicle endocytosis

Cellular Component

GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030425	dendrite
GO:0030665	clathrin-coated vesicle membrane
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0045202	synapse