Version 5.4
Mus musculus Protein: Col18a1
Summary
InnateDB Protein IDBP-166546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col18a1
Protein Name collagen, type XVIII, alpha 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000080358
InnateDB Gene IDBG-166544 (Col18a1)
Protein Structure
UniProt Annotation
Function Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in liver, kidney, lung, skeletal muscle and testis. {ECO:0000269PubMed:7876242}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001886 endothelial cell morphogenesis
GO:0007155 cell adhesion
GO:0008284 positive regulation of cell proliferation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0042493 response to drug
GO:0051599 response to hydrostatic pressure
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005581 collagen trimer
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:88451
InterPro IPR001791 Laminin G domain
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR010515 Collagenase NC10/endostatin
IPR016187 C-type lectin fold
PFAM PF00054
PF02210
PF01391
PF06482
PRINTS
PIRSF
SMART SM00210
SM00282
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P39061
PhosphoSite PhosphoSite-
TrEMBL D3Z556
UniProt Splice Variant
Entrez Gene 12822
UniGene Mm.4352
RefSeq NP_034059
MGI ID 1KOE
MGI Symbol Col18a1
OMIM
CCDS CCDS23953
HPRD
IMGT
EMBL AC055777 AC159334 AF257775 AK014292 AK031798 BC064817 BC066080 D17546 L16898 L22545 U03714 U03715 U03716 U03718 U11636 U11637 U34606 U34607 U34608 U34609 U34610 U34611 U34612 U34613
GenPept AAA19787 AAA20657 AAA37434 AAC52178 AAC52179 AAC52901 AAC52902 AAC52903 AAF69009 AAH64817 AAH66080 BAA04483 BAB29249 BAC27554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca