InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itgb2

Summary

InnateDB Protein

IDBP-167245.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb2

Protein Name

integrin beta 2

Synonyms

2E6; AI528527; Cd18; LAD; LCAMB; Lfa1; MF17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000299

InnateDB Gene

IDBG-167243 (Itgb2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0032403	protein complex binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002523	leukocyte migration involved in inflammatory response
GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0007568	aging
GO:0016337	single organismal cell-cell adhesion
GO:0030101	natural killer cell activation
GO:0030593	neutrophil chemotaxis
GO:0043542	endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0045123	cellular extravasation
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0050798	activated T cell proliferation
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0043235	receptor complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:96611

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References