Mus musculus Gene: Itgb2
Summary
InnateDB Gene IDBG-167243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgb2
Gene Name integrin beta 2
Synonyms 2E6; AI528527; Cd18; LAD; LCAMB; Lfa1; MF17;
Species Mus musculus
Ensembl Gene ENSMUSG00000000290
Encoded Proteins
integrin beta 2
integrin beta 2
integrin beta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.
Itgb2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs. (Demonstrated in human)
Itgax::Itgb2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)
[Homo sapiens] ITGB2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs.
[Homo sapiens] ITGAX::ITGB2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160255:
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:77530252-77565708
Strand Forward strand
Band C1
Transcripts
ENSMUST00000000299 ENSMUSP00000000299
ENSMUST00000131023 ENSMUSP00000119657
ENSMUST00000130059 ENSMUSP00000118191
ENSMUST00000156644 ENSMUSP00000137865
ENSMUST00000153541 ENSMUSP00000137734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0032403 protein complex binding
GO:0046982 protein heterodimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002523 leukocyte migration involved in inflammatory response
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0007568 aging
GO:0016337 single organismal cell-cell adhesion
GO:0030101 natural killer cell activation
GO:0030593 neutrophil chemotaxis
GO:0043542 endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045123 cellular extravasation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050798 activated T cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0043235 receptor complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Natural killer cell mediated cytotoxicity pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Leishmaniasis pathway
Malaria pathway
Amoebiasis pathway
Staphylococcus aureus infection pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Extracellular matrix organization pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Integrin cell surface interactions pathway
Immune System pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
Cell surface interactions at the vascular wall pathway
Extracellular matrix organization pathway
Hemostasis pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
Integrin cell surface interactions pathway
Adaptive Immune System pathway
Innate Immune System pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Natural killer cell mediated cytotoxicity pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Leishmaniasis pathway
Malaria pathway
Amoebiasis pathway
Staphylococcus aureus infection pathway
Viral myocarditis pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Integrin family cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
HIF-1-alpha transcription factor network
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1137 Mm.490467
RefSeq NM_008404 XM_006513271
OMIM
CCDS CCDS23956
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas