Version 5.4
Mus musculus Protein: Hsh2d
Summary
InnateDB Protein IDBP-167648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsh2d
Protein Name hematopoietic SH2 domain containing
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000071970
InnateDB Gene IDBG-167646 (Hsh2d)
Protein Structure
UniProt Annotation
Function Adapter protein involved in tyrosine kinase and CD28 signaling (By similarity). May be a modulator of the apoptotic response through its ability to affect mitochondrial stability. {ECO:0000250, ECO:0000269PubMed:15569688}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15569688}. Mitochondrion {ECO:0000269PubMed:15569688}.
Disease Associations
Tissue Specificity Predominantly expressed in spleen and thymus. Appears not to be expressed in heart, brain, liver, kidney, embryo, lung and ovary. {ECO:0000269PubMed:12960172}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0002903 negative regulation of B cell apoptotic process
GO:0009967 positive regulation of signal transduction
GO:0042110 T cell activation
GO:0051902 negative regulation of mitochondrial depolarization
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2676364
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6VYH9
PhosphoSite PhosphoSite-Q6VYH9
TrEMBL
UniProt Splice Variant
Entrez Gene 209488
UniGene Mm.157431
RefSeq NP_922935
MGI ID
MGI Symbol Hsh2d
OMIM
CCDS CCDS22410
HPRD
IMGT
EMBL AK157000 AY319653 BC094291
GenPept AAH94291 AAQ81286 BAE33927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca