Mus musculus Gene: Hsh2d
Summary
InnateDB Gene IDBG-167646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsh2d
Gene Name hematopoietic SH2 domain containing
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000062007
Encoded Proteins
hematopoietic SH2 domain containing
hematopoietic SH2 domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196684:
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:72189668-72200995
Strand Forward strand
Band B3.3
Transcripts
ENSMUST00000072097 ENSMUSP00000071970
ENSMUST00000165324 ENSMUSP00000127575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0002903 negative regulation of B cell apoptotic process
GO:0009967 positive regulation of signal transduction
GO:0042110 T cell activation
GO:0051902 negative regulation of mitochondrial depolarization
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q6VYH9
TrEMBL
UniProt Splice Variant
Entrez Gene 209488
UniGene Mm.157431
RefSeq NM_197944
OMIM
CCDS CCDS22410
HPRD
IMGT
MGI ID MGI:2676364
MGI Symbol Hsh2d
EMBL AK157000 AY319653 BC094291
GenPept AAH94291 AAQ81286 BAE33927
RNA Seq Atlas 209488