Version 5.4
Mus musculus Protein: Arfgap3
Summary
InnateDB Protein IDBP-168038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arfgap3
Protein Name ADP-ribosylation factor GTPase activating protein 3
Synonyms 0610009H19Rik; 1810004P07Rik; 1810035F16Rik; 9130416J18Rik; Arfgap1;
Species Mus musculus
Ensembl Protein ENSMUSP00000064893
InnateDB Gene IDBG-168036 (Arfgap3)
Protein Structure
UniProt Annotation
Function GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0009306 protein secretion
GO:0016192 vesicle-mediated transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1913501
InterPro IPR001164 Arf GTPase activating protein
PFAM PF01412
PRINTS PR00405
PIRSF
SMART SM00105
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D8S3
PhosphoSite PhosphoSite-Q9D8S3
TrEMBL
UniProt Splice Variant
Entrez Gene 66251
UniGene Mm.473149
RefSeq NP_079721
MGI ID
MGI Symbol Arfgap3
OMIM
CCDS CCDS49683
HPRD
IMGT
EMBL AK007732 AK028990 AK075788 AK169107 BC004081 BC060369
GenPept AAH04081 AAH60369 BAB25220 BAC26229 BAC35959 BAE40889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca