Version 5.4
Homo sapiens Protein: NECAP1
Summary
InnateDB Protein IDBP-16817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NECAP1
Protein Name NECAP endocytosis associated 1
Synonyms EIEE21;
Species Homo sapiens
Ensembl Protein ENSP00000341737
InnateDB Gene IDBG-16815 (NECAP1)
Protein Structure
UniProt Annotation
Function Involved in endocytosis. {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with AP-2 at the plasma membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0030125 clathrin vesicle coat
Protein Structure and Domains
PDB ID
InterPro IPR012466 Adaptin ear-binding coat-associated protein 1 NECAP-1
PFAM PF07933
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NC96
PhosphoSite PhosphoSite-Q8NC96
TrEMBL F5H2U7
UniProt Splice Variant
Entrez Gene 25977
UniGene Hs.625253
RefSeq NP_056324
HUGO HGNC:24539
OMIM 611623
CCDS CCDS8589
HPRD 14819
IMGT
EMBL AC006511 AK074858 AK074880 AK074923 AK075013 AK290537 AL050272 BC002888 BC067367 BC084551 BC110876 CH471116
GenPept AAH02888 AAH67367 AAH84551 AAI10877 BAC11250 BAC11264 BAC11296 BAC11352 BAF83226 CAB43373 EAW88636 EAW88638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca