Homo sapiens Gene: NECAP1
Summary
InnateDB Gene IDBG-16815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NECAP1
Gene Name NECAP endocytosis associated 1
Synonyms EIEE21;
Species Homo sapiens
Ensembl Gene ENSG00000089818
Encoded Proteins
NECAP endocytosis associated 1
NECAP endocytosis associated 1
NECAP endocytosis associated 1
NECAP endocytosis associated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8082211-8097771
Strand Forward strand
Band p13.31
Transcripts
ENST00000339754 ENSP00000341737
ENST00000450991 ENSP00000401963
ENST00000546181
ENST00000542095
ENST00000545807
ENST00000544891
ENST00000541948 ENSP00000440658
ENST00000540083 ENSP00000439319
ENST00000537796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0030125 clathrin vesicle coat
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Golgi Associated Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F5H2U7
UniProt Splice Variant
Entrez Gene 25977
UniGene Hs.555927 Hs.625253
RefSeq NM_015509
HUGO HGNC:24539
OMIM 611623
CCDS CCDS8589
HPRD 14819
IMGT
EMBL AC006511
GenPept
RNA Seq Atlas 25977