InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Maml1

Summary

InnateDB Protein

IDBP-168557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Maml1

Protein Name

mastermind like 1 (Drosophila)

Synonyms

AI644666; AW743257; D930008C07Rik; Mam-1; Mam1; mKIAA0200;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059210

InnateDB Gene

IDBG-168553 (Maml1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269PubMed:15019995, ECO:0000269PubMed:15187027}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:15019995}. Note=Nuclear, in a punctate manner.

Disease Associations

Tissue Specificity

At E9.5, strongly expressed in the telencephalon, first branchial arch, forelimb buds and somites. By E10.5, continuously expressed in brain and spinal cord. Also expressed in first and second branchial arches and limb buds. By E11.5, expression in CNS is weak but increases in mesodermal tissues. At E14.5, detected in epithelial cells in trachea, esophagus and proximal and distal tubules of the developing lungs. {ECO:0000269PubMed:15019995}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042605	peptide antigen binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007219	Notch signaling pathway
GO:0010831	positive regulation of myotube differentiation
GO:0045445	myoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051149	positive regulation of muscle cell differentiation
GO:0060928	atrioventricular node cell development

Cellular Component

GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016607	nuclear speck
GO:0043231	intracellular membrane-bounded organelle