Mus musculus Gene: Maml1
Summary
InnateDB Gene IDBG-168553.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Maml1
Gene Name mastermind like 1 (Drosophila)
Synonyms AI644666; AW743257; D930008C07Rik; Mam-1; Mam1; mKIAA0200;
Species Mus musculus
Ensembl Gene ENSMUSG00000050567
Encoded Proteins
mastermind like 1 (Drosophila)
mastermind like 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161021:
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:50255634-50292311
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000059458 ENSMUSP00000059210
ENSMUST00000135868 ENSMUSP00000118188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042605 peptide antigen binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007219 Notch signaling pathway
GO:0010831 positive regulation of myotube differentiation
GO:0045445 myoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051149 positive regulation of muscle cell differentiation
GO:0060928 atrioventricular node cell development
Cellular Component
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
NOTCH2 intracellular domain regulates transcription pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Notch-HLH transcription pathway pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Pre-NOTCH Expression and Processing pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Pre-NOTCH Transcription and Translation pathway
Gene Expression pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
Signaling by NOTCH pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
KEGG
Notch signaling pathway pathway
INOH
BMP2 signaling pathway
TGF-beta signaling pathway
Notch signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Notch pathway
REACTOME
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Pre-NOTCH Expression and Processing pathway
Notch-HLH transcription pathway pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Pre-NOTCH Transcription and Translation pathway
Signaling by NOTCH2 pathway
Generic Transcription Pathway pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
NOTCH2 intracellular domain regulates transcription pathway
Gene Expression pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
KEGG
Notch signaling pathway pathway
INOH
TGF-beta signaling pathway
BMP2 signaling pathway
Notch signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6T264
TrEMBL
UniProt Splice Variant
Entrez Gene 103806
UniGene Mm.408389 Mm.473242 Mm.51116
RefSeq NM_175334
OMIM
CCDS CCDS24632
HPRD
IMGT
MGI ID MGI:1890504
MGI Symbol Maml1
EMBL AK086146 AK129088 AL646002 AY442299 BC024668 BC058658 BC094599
GenPept AAH24668 AAH58658 AAH94599 AAS07633 BAC39618 BAC97898 CAI24683
RNA Seq Atlas 103806