Version 5.4
Mus musculus Protein: Cpn1
Summary
InnateDB Protein IDBP-168897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpn1
Protein Name carboxypeptidase N, polypeptide 1
Synonyms 0610011F20Rik; CPN;
Species Mus musculus
Ensembl Protein ENSMUSP00000026210
InnateDB Gene IDBG-168895 (Cpn1)
Protein Structure
UniProt Annotation
Function Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. {ECO:0000250}.
Subcellular Localization Secreted, extracellular space {ECO:0000269PubMed:10878383}.
Disease Associations
Tissue Specificity Mainly expressed in liver. Also detected in lung, stomach, intestine, spleen and kidney. {ECO:0000269PubMed:10878383, ECO:0000269PubMed:11342641}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0010815 bradykinin catabolic process
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:2135874
InterPro IPR000834 Peptidase M14, carboxypeptidase A
IPR008969 Carboxypeptidase-like, regulatory domain
PFAM PF00246
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJN5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 93721
UniGene Mm.206774
RefSeq NP_109628
MGI ID
MGI Symbol Cpn1
OMIM
CCDS CCDS29840
HPRD
IMGT
EMBL AB021969 AF326477 BC014692
GenPept AAH14692 AAK06821 BAB03403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca