Version 5.4
| Mus musculus Protein: Glrx5 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Protein | IDBP-168903.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Glrx5 | ||||||||||||
| Protein Name | glutaredoxin 5 homolog (S. cerevisiae) | ||||||||||||
| Synonyms | 2310004O13Rik; 2900070E19Rik; AU020725; | ||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Protein | ENSMUSP00000021522 | ||||||||||||
| InnateDB Gene | IDBG-168901 (Glrx5) | ||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||
| Function | Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress. {ECO:0000269PubMed:19442627}. | ||||||||||||
| Subcellular Localization | Mitochondrion {ECO:0000250}. | ||||||||||||
| Disease Associations | |||||||||||||
| Tissue Specificity | Detected in bone, liver, muscle and kidney. {ECO:0000269PubMed:19442627}. | ||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||
| PDB ID | MGI:1920296 | ||||||||||||
| InterPro |
IPR002109
Glutaredoxin IPR004480 Monothiol glutaredoxin-related IPR012336 Thioredoxin-like fold |
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| PFAM |
PF00462
PF13098 PF13192 PF13462 PF13905 |
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| PRINTS | |||||||||||||
| PIRSF | |||||||||||||
| SMART | |||||||||||||
| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q80Y14 | ||||||||||||
| PhosphoSite | PhosphoSite-Q80Y14 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 73046 | ||||||||||||
| UniGene | |||||||||||||
| RefSeq | NP_082695 | ||||||||||||
| MGI ID | |||||||||||||
| MGI Symbol | Glrx5 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS26154 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | AK013761 AK050883 BC050937 BC058371 DQ083330 | ||||||||||||
| GenPept | AAH50937 AAH58371 AAZ30730 BAB28985 BAC34443 | ||||||||||||