InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp46a1

Summary

InnateDB Protein

IDBP-170557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp46a1

Protein Name

cytochrome P450, family 46, subfamily a, polypeptide 1

Synonyms

Cyp46;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021684

InnateDB Gene

IDBG-170555 (Cyp46a1)

Protein Structure

UniProt Annotation

Function

Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in high level in brain (cerebral cortex, hippocampus, dentate gyrus and thalamus) and in lower levels in testis and liver. Brain's expression increased linearly with age.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033781	cholesterol 24-hydroxylase activity