InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRF2

Summary

InnateDB Protein

IDBP-17069.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRF2

Protein Name

BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000220659

InnateDB Gene

IDBG-17067 (BRF2)

Protein Structure

UniProt Annotation

Function

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. {ECO:0000269PubMed:11040218, ECO:0000269PubMed:11121026, ECO:0000269PubMed:11564744}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17505538}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	28 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0010467	gene expression