Homo sapiens Gene: BRF2
Summary
InnateDB Gene IDBG-17067.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRF2
Gene Name BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104221
Encoded Proteins
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:37843268-37849904
Strand Reverse strand
Band p11.23
Transcripts
ENST00000220659 ENSP00000220659
ENST00000520601 ENSP00000430107
ENST00000521170 ENSP00000430193
ENST00000522539 ENSP00000429554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 28 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0010467 gene expression
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
RNA Polymerase III Transcription Initiation pathway
RNA Polymerase III Transcription pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9HAW0
TrEMBL E5RGF6 E5RGX1
UniProt Splice Variant
Entrez Gene 55290
UniGene Hs.709301
RefSeq NM_018310
HUGO HGNC:17298
OMIM 607013
CCDS CCDS6098
HPRD
IMGT
EMBL AC130304 AC138356 AF130058 AF206673 AF298153 AK001914 AK315420 BC010648 CH471080
GenPept AAG30222 AAG35486 AAG35669 AAH10648 BAA91975 BAG37809 EAW63351 EAW63352 EAW63353
RNA Seq Atlas 55290