InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLPX

Summary

InnateDB Protein

IDBP-17072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLPX

Protein Name

ClpX caseinolytic peptidase X homolog (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300107

InnateDB Gene

IDBG-17070 (CLPX)

Protein Structure

UniProt Annotation

Function

ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. {ECO:0000269PubMed:11923310, ECO:0000269PubMed:22710082, ECO:0000269PubMed:22841477}.

Subcellular Localization

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Disease Associations

Tissue Specificity

Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas. {ECO:0000269PubMed:11003706}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004176	ATP-dependent peptidase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016504	peptidase activator activity
GO:0016887	ATPase activity
GO:0046872	metal ion binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006457	protein folding
GO:0010952	positive regulation of peptidase activity
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0009368	endopeptidase Clp complex
GO:0009841	mitochondrial endopeptidase Clp complex
GO:0042645	mitochondrial nucleoid

Protein Structure and Domains

PDB ID

InterPro

IPR002078 RNA polymerase sigma factor 54 interaction domain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR004487 Clp protease, ATP-binding subunit ClpX
IPR011704 ATPase, dynein-related, AAA domain
IPR019489 Clp ATPase, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00158
PF00004
PF07724
PF13304
PF07728
PF10431

PRINTS

PIRSF

SMART

SM00382
SM01086

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O76031