InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H2-Ab1

Summary

InnateDB Protein

IDBP-170863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2-Ab1

Protein Name

histocompatibility 2, class II antigen A, beta 1

Synonyms

Abeta; AI845868; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2; IAb; Rmcs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041008

InnateDB Gene

IDBG-170861 (H2-Ab1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0015643	toxic substance binding
GO:0031625	ubiquitin protein ligase binding
GO:0042605	peptide antigen binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0002344	B cell affinity maturation
GO:0002579	positive regulation of antigen processing and presentation
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045087	innate immune response (InnateDB)
GO:0046635	positive regulation of alpha-beta T cell activation
GO:0048002	antigen processing and presentation of peptide antigen
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005622	intracellular
GO:0005769	early endosome
GO:0005771	multivesicular body
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042613	MHC class II protein complex

Protein Structure and Domains

PDB ID

MGI:103070

InterPro

IPR000353 MHC class II, beta chain, N-terminal
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF00969
PF07654
PF08205

PRINTS

PIRSF

SMART

SM00921
SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P14483