InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: H2-Ab1

Summary

InnateDB Gene

IDBG-170861.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2-Ab1

Gene Name

histocompatibility 2, class II antigen A, beta 1

Synonyms

Abeta; AI845868; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2; IAb; Rmcs1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000073421

Encoded Proteins

IDBP-170863

histocompatibility 2, class II antigen A, beta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21441935

H2-Ab1 is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179344:
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34263209-34269418

Strand

Forward strand

Band

Transcripts

ENSMUST00000040828	ENSMUSP00000041008
ENSMUST00000173103
ENSMUST00000174875

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0015643	toxic substance binding
GO:0031625	ubiquitin protein ligase binding
GO:0042605	peptide antigen binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0002344	B cell affinity maturation
GO:0002579	positive regulation of antigen processing and presentation
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045087	innate immune response (InnateDB)
GO:0046635	positive regulation of alpha-beta T cell activation
GO:0048002	antigen processing and presentation of peptide antigen
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005622	intracellular
GO:0005769	early endosome
GO:0005771	multivesicular body
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042613	MHC class II protein complex