Mus musculus Gene: H2-Ab1
Summary
InnateDB Gene IDBG-170861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2-Ab1
Gene Name histocompatibility 2, class II antigen A, beta 1
Synonyms Abeta; AI845868; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2; IAb; Rmcs1;
Species Mus musculus
Ensembl Gene ENSMUSG00000073421
Encoded Proteins
histocompatibility 2, class II antigen A, beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
H2-Ab1 is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179344:
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34263209-34269418
Strand Forward strand
Band B1
Transcripts
ENSMUST00000040828 ENSMUSP00000041008
ENSMUST00000173103
ENSMUST00000174875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0015643 toxic substance binding
GO:0031625 ubiquitin protein ligase binding
GO:0042605 peptide antigen binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0002344 B cell affinity maturation
GO:0002579 positive regulation of antigen processing and presentation
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045087 innate immune response (InnateDB)
GO:0046635 positive regulation of alpha-beta T cell activation
GO:0048002 antigen processing and presentation of peptide antigen
GO:0071346 cellular response to interferon-gamma
Cellular Component
GO:0005622 intracellular
GO:0005769 early endosome
GO:0005771 multivesicular body
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042613 MHC class II protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
PD-1 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
MHC class II antigen presentation pathway
Translocation of ZAP-70 to Immunological synapse pathway
Costimulation by the CD28 family pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P14483
TrEMBL O19455 Q3TD53 Q7YQ01 Q7YQ02
UniProt Splice Variant
Entrez Gene 14961
UniGene Mm.254067
RefSeq NM_207105
OMIM
CCDS CCDS37583
HPRD
IMGT
MGI ID MGI:103070
MGI Symbol H2-Ab1
EMBL AF027865 AK170370 AY303784 AY303785 CH466660 K00118 K00119 K00120 K00121 K00122 V01527
GenPept AAA39542 AAB81531 AAP69831 AAP69832 BAE41751 CAA24768 EDL10266
RNA Seq Atlas 14961