InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Des

Summary

InnateDB Protein

IDBP-170901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Des

Protein Name

desmin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027409

InnateDB Gene

IDBG-170899 (Des)

Protein Structure

UniProt Annotation

Function

Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007517

muscle organ development

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005882	intermediate filament
GO:0005916	fascia adherens
GO:0030018	Z disc
GO:0031594	neuromuscular junction
GO:0042383	sarcolemma
GO:0043292	contractile fiber