InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H2-Aa

Summary

InnateDB Protein

IDBP-170984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2-Aa

Protein Name

histocompatibility 2, class II antigen A, alpha

Synonyms

Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1; IAalpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046105

InnateDB Gene

IDBG-170982 (H2-Aa)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042605	peptide antigen binding

Biological Process

GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0034341	response to interferon-gamma
GO:0045087	innate immune response (InnateDB)
GO:0045582	positive regulation of T cell differentiation
GO:0048002	antigen processing and presentation of peptide antigen

Cellular Component

GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042613	MHC class II protein complex

Protein Structure and Domains

PDB ID

MGI:95895

InterPro

IPR001003 MHC class II, alpha chain, N-terminal
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein

PFAM

PF00993
PF07654

PRINTS

PIRSF

SMART

SM00920
SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P14434