InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trh

Summary

InnateDB Protein

IDBP-171095.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trh

Protein Name

thyrotropin releasing hormone

Synonyms

Pro-TRH; Trf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006046

InnateDB Gene

IDBG-171093 (Trh)

Protein Structure

UniProt Annotation

Function

Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Specifically expressed in hypothalamus and testis. {ECO:0000269PubMed:1323011}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding
GO:0008437	thyrotropin-releasing hormone activity

Biological Process

GO:0001666	response to hypoxia
GO:0001692	histamine metabolic process
GO:0007628	adult walking behavior
GO:0009409	response to cold
GO:0009749	response to glucose
GO:0009755	hormone-mediated signaling pathway
GO:0014050	negative regulation of glutamate secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014070	response to organic cyclic compound
GO:0032024	positive regulation of insulin secretion
GO:0042755	eating behavior
GO:0045471	response to ethanol
GO:0051412	response to corticosterone
GO:2000252	negative regulation of feeding behavior