Version 5.4
Mus musculus Gene: Trh
Summary
InnateDB Gene IDBG-171093.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trh
Gene Name thyrotropin releasing hormone
Synonyms Pro-TRH; Trf
Species Mus musculus
Ensembl Gene ENSMUSG00000005892
Encoded Proteins
IDBP-171095
thyrotropin releasing hormone
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The mouse proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Disruption of this gene results in hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:92242061-92244650
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000006046 ENSMUSP00000006046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
GO:0008437 thyrotropin-releasing hormone activity
Biological Process
GO:0001666 response to hypoxia
GO:0001692 histamine metabolic process
GO:0007628 adult walking behavior
GO:0009409 response to cold
GO:0009749 response to glucose
GO:0009755 hormone-mediated signaling pathway
GO:0014050 negative regulation of glutamate secretion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0014070 response to organic cyclic compound
GO:0032024 positive regulation of insulin secretion
GO:0042755 eating behavior
GO:0045471 response to ethanol
GO:0051412 response to corticosterone
GO:2000252 negative regulation of feeding behavior
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000170893
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1363
RefSeq NM_009426
OMIM
CCDS CCDS20375
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca