Mus musculus Gene: Trh
Summary
InnateDB Gene IDBG-171093.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trh
Gene Name thyrotropin releasing hormone
Synonyms Pro-TRH; Trf
Species Mus musculus
Ensembl Gene ENSMUSG00000005892
Encoded Proteins
thyrotropin releasing hormone
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The mouse proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Disruption of this gene results in hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:92242061-92244650
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000006046 ENSMUSP00000006046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
GO:0008437 thyrotropin-releasing hormone activity
Biological Process
GO:0001666 response to hypoxia
GO:0001692 histamine metabolic process
GO:0007628 adult walking behavior
GO:0009409 response to cold
GO:0009749 response to glucose
GO:0009755 hormone-mediated signaling pathway
GO:0014050 negative regulation of glutamate secretion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0014070 response to organic cyclic compound
GO:0032024 positive regulation of insulin secretion
GO:0042755 eating behavior
GO:0045471 response to ethanol
GO:0051412 response to corticosterone
GO:2000252 negative regulation of feeding behavior
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
KEGG
INOH
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1363
RefSeq NM_009426
OMIM
CCDS CCDS20375
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas