InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gapdhs

Summary

InnateDB Protein

IDBP-171178.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gapdhs

Protein Name

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

Synonyms

Gapd-s; Gapds;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074317

InnateDB Gene

IDBG-171174 (Gapdhs)

Protein Structure

UniProt Annotation

Function

May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility. {ECO:0000269PubMed:15546993}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515	protein binding
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0007286	spermatid development
GO:0030317	sperm motility
GO:0045821	positive regulation of glycolytic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005929	cilium
GO:0031514	motile cilium
GO:0035686	sperm fibrous sheath
GO:0097228	sperm principal piece

Protein Structure and Domains

PDB ID

MGI:95653

InterPro

IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I
IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain
IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family

PFAM

PF00044
PF02800

PRINTS

PR00078

PIRSF

PIRSF000149

SMART

SM00846

TIGRFAMs

Post-translational Modifications

Modification

Cross-References