InnateDB Protein
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IDBP-171528.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Stra6
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Protein Name
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stimulated by retinoic acid gene 6
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Synonyms
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AI891933;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034880
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InnateDB Gene
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IDBG-171524 (Stra6)
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Protein Structure
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Function |
May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:9203140}; Multi-pass membrane protein {ECO:0000269PubMed:9203140}. Note=Plasma membrane of the basal pole of Sertoli cells, absent in plasma membrane of neighboring spermatogonia.
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Disease Associations |
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Tissue Specificity |
Widely expressed in the embryo. In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in the eye (retinal pigment epithelium), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta (at protein level). Also detected in kidney, spleen, and female genital tract; and at lower levels in heart and lung. Not detected in liver. {ECO:0000269PubMed:9203140}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107742
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O70491
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PhosphoSite |
PhosphoSite-O70491
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TrEMBL |
E9QAQ2
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UniProt Splice Variant |
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Entrez Gene |
20897
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UniGene |
Mm.10801
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RefSeq |
NP_033317
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MGI ID |
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MGI Symbol |
Stra6
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OMIM |
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CCDS |
CCDS23236
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HPRD |
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IMGT |
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EMBL |
AC158996
AF062476
BC075657
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GenPept |
AAC16016
AAH75657
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