Mus musculus Protein: Ffar1 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-171556.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Ffar1 | ||||||
Protein Name | free fatty acid receptor 1 | ||||||
Synonyms | |||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000055564 | ||||||
InnateDB Gene | IDBG-171554 (Ffar1) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway. {ECO:0000269PubMed:12629551}. | ||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
Disease Associations | |||||||
Tissue Specificity | Expressed in the pancreatic islet-beta cells. {ECO:0000269PubMed:12496284}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:2684079 | ||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR013312 G protein-coupled receptor 40-related receptor IPR013313 GPR40 receptor fatty acid IPR017452 GPCR, rhodopsin-like, 7TM |
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PFAM |
PF00001
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PRINTS |
PR00237
PR01904 PR01905 |
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PIRSF | |||||||
SMART | |||||||
TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q76JU9 | ||||||
PhosphoSite | PhosphoSite-Q76JU9 | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 233081 | ||||||
UniGene | Mm.425422 | ||||||
RefSeq | NP_918946 | ||||||
MGI ID | |||||||
MGI Symbol | Ffar1 | ||||||
OMIM | |||||||
CCDS | CCDS21113 | ||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AB095745 AF539809 BC132014 BC138099 | ||||||
GenPept | AAI32015 AAI38100 AAN03478 BAC82555 | ||||||