Version 5.4
Mus musculus Protein: Ucp1
Summary
InnateDB Protein IDBP-171840.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ucp1
Protein Name uncoupling protein 1 (mitochondrial, proton carrier)
Synonyms AI385626; Slc25a7; Ucp;
Species Mus musculus
Ensembl Protein ENSMUSP00000034146
InnateDB Gene IDBG-171838 (Ucp1)
Protein Structure
UniProt Annotation
Function UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Subcellular Localization Mitochondrion inner membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Brown adipose tissue.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017077 oxidative phosphorylation uncoupler activity
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006839 mitochondrial transport
GO:0015992 proton transport
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:98894
InterPro IPR002030 Mitochondrial brown fat uncoupling protein
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS PR00784
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P12242
PhosphoSite PhosphoSite-P12242
TrEMBL
UniProt Splice Variant
Entrez Gene 22227
UniGene
RefSeq NP_033489
MGI ID
MGI Symbol Ucp1
OMIM
CCDS CCDS22449
HPRD
IMGT
EMBL BC012701 M21222 M21244 M21245 M21246 M21247 U63418 U63419
GenPept AAA40521 AAB05870 AAB07367 AAH12701

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca