InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ucp1

Summary

InnateDB Gene

IDBG-171838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ucp1

Gene Name

uncoupling protein 1 (mitochondrial, proton carrier)

Synonyms

AI385626; Slc25a7; Ucp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031710

Encoded Proteins

IDBP-171840

uncoupling protein 1 (mitochondrial, proton carrier)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109424:
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:83290348-83298456

Strand

Forward strand

Band

Transcripts

ENSMUST00000034146

ENSMUSP00000034146

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017077	oxidative phosphorylation uncoupler activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006839	mitochondrial transport
GO:0015992	proton transport
GO:0050873	brown fat cell differentiation