InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfyve16

Summary

InnateDB Protein

IDBP-172130.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfyve16

Protein Name

zinc finger, FYVE domain containing 16

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022217

InnateDB Gene

IDBG-172128 (Zfyve16)

Protein Structure

UniProt Annotation

Function

May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P) (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008565	protein transporter activity
GO:0046872	metal ion binding

Biological Process

GO:0006622	protein targeting to lysosome
GO:0016197	endosomal transport

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:2145181

InterPro

IPR000306 FYVE zinc finger
IPR011011 Zinc finger, FYVE/PHD-type
IPR017165 Zinc finger, FYVE-type, SARA/endofin
IPR017455 Zinc finger, FYVE-related
IPR022557 Domain of unknown function DUF3480

PFAM

PF01363
PF11979

PRINTS

PIRSF

PIRSF037289

SMART

SM00064

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt