InnateDB Protein
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IDBP-17224.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DOHH
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Protein Name
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deoxyhypusine hydroxylase/monooxygenase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000250937
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InnateDB Gene
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IDBG-17222 (DOHH)
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Protein Structure
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Function |
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor. {ECO:0000255HAMAP-Rule:MF_03101, ECO:0000269PubMed:16371467, ECO:0000269PubMed:19706422}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004155
PBS lyase HEAT-like repeat
IPR016024
Armadillo-type fold
IPR021133
HEAT, type 2
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PFAM |
PF03130
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PRINTS |
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PIRSF |
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SMART |
SM00567
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BU89
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PhosphoSite |
PhosphoSite-Q9BU89
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TrEMBL |
K7EIV2
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UniProt Splice Variant |
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Entrez Gene |
83475
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UniGene |
Hs.515064
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RefSeq |
NP_112594
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HUGO |
HGNC:28662
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OMIM |
611262
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CCDS |
CCDS12108
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HPRD |
14627
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IMGT |
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EMBL |
AC005551
AC005787
AC093052
BC002817
BC009863
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GenPept |
AAC33193
AAH02817
AAH09863
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