Version 5.4
Homo sapiens Gene: DOHH
Summary
InnateDB Gene IDBG-17222.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOHH
Gene Name deoxyhypusine hydroxylase/monooxygenase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129932
Encoded Proteins
IDBP-17224
deoxyhypusine hydroxylase/monooxygenase
IDBP-364087
deoxyhypusine hydroxylase/monooxygenase
IDBP-760193
IDBP-761612
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3490821-3500940
Strand Reverse strand
Band p13.3
Transcripts
ENST00000250937 ENSP00000250937
ENST00000427575 ENSP00000398882
ENST00000592858 ENSP00000464905
ENST00000586906
ENST00000587122 ENSP00000468416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0019135 deoxyhypusine monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078440
View Gene Order
ENSBTAG00000005272
Not yet available
Pathways
NETPATH
REACTOME
REACT_12469
Hypusine synthesis from eIF5A-lysine pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515064
RefSeq NM_001145165 NM_031304
HUGO
OMIM
CCDS CCDS12108
HPRD 14627
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca