InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fdft1

Summary

InnateDB Protein

IDBP-172373.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fdft1

Protein Name

farnesyl diphosphate farnesyl transferase 1

Synonyms

SQS; SS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055313

InnateDB Gene

IDBG-172371 (Fdft1)

Protein Structure

UniProt Annotation

Function

Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004310	farnesyl-diphosphate farnesyltransferase activity
GO:0016491	oxidoreductase activity
GO:0016740	transferase activity
GO:0051996	squalene synthase activity

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0008610	lipid biosynthetic process
GO:0009058	biosynthetic process
GO:0045338	farnesyl diphosphate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle