InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fdft1

Summary

InnateDB Gene

IDBG-172371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fdft1

Gene Name

farnesyl diphosphate farnesyl transferase 1

Synonyms

SQS; SS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021273

Encoded Proteins

IDBP-172373

farnesyl diphosphate farnesyl transferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079459:
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:63145153-63177793

Strand

Reverse strand

Band

Transcripts

ENSMUST00000054963

ENSMUSP00000055313

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004310	farnesyl-diphosphate farnesyltransferase activity
GO:0016491	oxidoreductase activity
GO:0016740	transferase activity
GO:0051996	squalene synthase activity

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0008610	lipid biosynthetic process
GO:0009058	biosynthetic process
GO:0045338	farnesyl diphosphate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle