InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mitf

Summary

InnateDB Protein

IDBP-172463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mitf

Protein Name

microphthalmia-associated transcription factor

Synonyms

BCC2; Bhlhe32; bw; Gsfbcc2; mi; vit; Vitiligo; Wh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044938

InnateDB Gene

IDBG-172461 (Mitf)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0010468	regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030316	osteoclast differentiation
GO:0030318	melanocyte differentiation
GO:0042127	regulation of cell proliferation
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043473	pigmentation
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165	cell fate commitment
GO:0045670	regulation of osteoclast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046849	bone remodeling