Version 5.4
Mus musculus Protein: Psd
Summary
InnateDB Protein IDBP-172697.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psd
Protein Name pleckstrin and Sec7 domain containing
Synonyms 1110007H17Rik; A930015K15; Efa6; Efa6a; mKIAA2011; Psdl;
Species Mus musculus
Ensembl Protein ENSMUSP00000039728
InnateDB Gene IDBG-172695 (Psd)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor for ARF6. Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers. {ECO:0000269PubMed:19494129}.
Subcellular Localization Isoform 1: Cell membrane. Cell projection, ruffle. Note=Colocalizes with ACTN1 in membrane ruffles and central reticular structures.Isoform 2: Cell membrane. Cell projection. Note=Accumulates in microvilli-like protrusions.Isoform 3: Cell membrane. Cell projection, ruffle. Note=Colocalizes with F-actin in membrane ruffles.
Disease Associations
Tissue Specificity Isoform 1 is highly expressed in the strata oriens, radiatum, lacunosum-moleculare of the hippocampal CA1-3 regions and the dentate molecular layer of the hippocampal formation, with lower levels detected in the neuronal cell layers and the stratum lucidum (at protein level). Highest expression detected in brain and some expression detected also in uterus, stomach, ovary and intestine, with isoform 2 being expressed at the highest levels. Not detected in tongue, thymus, spleen, lung, heart, liver and kidney. {ECO:0000269PubMed:17298598, ECO:0000269PubMed:19494129}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005543 phospholipid binding
Biological Process
GO:0030182 neuron differentiation
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0001726 ruffle
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:1920978
InterPro IPR000904 Sec7 domain
IPR001605 Pleckstrin homology domain, spectrin-type
IPR001849 Pleckstrin homology domain
PFAM PF01369
PF00169
PRINTS PR00683
PIRSF
SMART SM00222
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5DTT2
PhosphoSite PhosphoSite-Q5DTT2
TrEMBL
UniProt Splice Variant
Entrez Gene 73728
UniGene Mm.487512
RefSeq NP_082903
MGI ID
MGI Symbol Psd
OMIM
CCDS CCDS29875
HPRD
IMGT
EMBL AC114539 AK158851 AK220438 BC058352 BC138652 BC145352
GenPept AAH58352 AAI38653 AAI45353 BAD90268 BAE34694

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca