Mus musculus Protein: Cdc42bpb | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-172725.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Cdc42bpb | ||||||||||||||||||||||
Protein Name | CDC42 binding protein kinase beta | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000042565 | ||||||||||||||||||||||
InnateDB Gene | IDBG-172723 (Cdc42bpb) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell- cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating and wounded cells; this localization requires the presence of catalytically active CDC42 (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:2136459 | ||||||||||||||||||||||
InterPro |
IPR000095
CRIB domain IPR000719 Protein kinase domain IPR000961 AGC-kinase, C-terminal IPR001180 Citron-like IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001849 Pleckstrin homology domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR014930 Myotonic dystrophy protein kinase, coiled coil IPR017892 Protein kinase, C-terminal IPR020454 Diacylglycerol/phorbol-ester binding IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00786
PF00069 PF00780 PF07714 PF00169 PF00130 PF08826 PF00433 |
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PRINTS |
PR00109
PR00008 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00285
SM00133 SM00036 SM00233 SM00109 SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q7TT50 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q7TT50 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 217866 | ||||||||||||||||||||||
UniGene | Mm.485798 | ||||||||||||||||||||||
RefSeq | NP_898837 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Cdc42bpb | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS26176 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC127580 AK173103 AY277589 BC049921 | ||||||||||||||||||||||
GenPept | AAH49921 AAP34402 BAD32381 | ||||||||||||||||||||||