InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tdh

Summary

InnateDB Protein

IDBP-172749.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdh

Protein Name

L-threonine dehydrogenase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022522

InnateDB Gene

IDBG-172747 (Tdh)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion {ECO:0000250UniProtKB:Q8MIR0}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008743	L-threonine 3-dehydrogenase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662	coenzyme binding

Biological Process

GO:0006567	threonine catabolic process
GO:0006694	steroid biosynthetic process
GO:0019518	L-threonine catabolic process to glycine
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1926231

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR013120 Male sterility, NAD-binding

PFAM

PF01370
PF01073
PF04321
PF07993

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K3F7

PhosphoSite