Version 5.4
Mus musculus Protein: March7
Summary
InnateDB Protein IDBP-172918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol March7
Protein Name membrane-associated ring finger (C3HC4) 7
Synonyms Axo; Axot; Gtrgeo17;
Species Mus musculus
Ensembl Protein ENSMUSP00000099808
InnateDB Gene IDBG-172914 (March7)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. {ECO:0000269PubMed:15670816}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in brain, thymus, muscle and kidney. {ECO:0000269PubMed:15670816}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1931053
InterPro IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF12906
PF00097
PRINTS
PIRSF
SMART SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WV66
PhosphoSite PhosphoSite-Q9WV66
TrEMBL
UniProt Splice Variant
Entrez Gene 57438
UniGene Mm.410136
RefSeq XP_006500011
MGI ID
MGI Symbol March7
OMIM
CCDS CCDS16057
HPRD
IMGT
EMBL AF155739 AK166666 AK167246 AK168555 BC025029
GenPept AAD38411 AAH25029 BAE38928 BAE39367 BAE40429

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca