Homo sapiens Protein: ITPK1
Summary
InnateDB Protein IDBP-17299.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPK1
Protein Name inositol-tetrakisphosphate 1-kinase
Synonyms ITRPK1;
Species Homo sapiens
Ensembl Protein ENSP00000346272
InnateDB Gene IDBG-17293 (ITPK1)
Protein Structure
UniProt Annotation
Function Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. {ECO:0000269PubMed:11909533, ECO:0000269PubMed:12925536, ECO:0000269PubMed:17616525}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269PubMed:8662638}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0047325 inositol tetrakisphosphate 1-kinase activity
GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity
GO:0052825 inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
GO:0052830 inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
GO:0052831 inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
GO:0052835 inositol-3,4,6-trisphosphate 1-kinase activity
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0016310 phosphorylation
GO:0016311 dephosphorylation
GO:0032957 inositol trisphosphate metabolic process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR008656 Inositol-tetrakisphosphate 1-kinase
PFAM PF05770
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13572
PhosphoSite PhosphoSite-Q13572
TrEMBL G3V588
UniProt Splice Variant
Entrez Gene 3705
UniGene Hs.308122
RefSeq NP_001136066
HUGO HGNC:6177
OMIM 601838
CCDS CCDS45157
HPRD 03501
IMGT
EMBL AF279372 AL110118 AL117192 BC003622 BC007428 BC018192 U51336
GenPept AAC50483 AAG44835 AAH03622 AAH07428 AAH18192