InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITPK1

Summary

InnateDB Protein

IDBP-17299.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITPK1

Protein Name

inositol-tetrakisphosphate 1-kinase

Synonyms

ITRPK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000346272

InnateDB Gene

IDBG-17293 (ITPK1)

Protein Structure

UniProt Annotation

Function

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. {ECO:0000269PubMed:11909533, ECO:0000269PubMed:12925536, ECO:0000269PubMed:17616525}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269PubMed:8662638}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0016853	isomerase activity
GO:0047325	inositol tetrakisphosphate 1-kinase activity
GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity
GO:0052825	inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
GO:0052830	inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
GO:0052831	inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
GO:0052835	inositol-3,4,6-trisphosphate 1-kinase activity

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0016311	dephosphorylation
GO:0032957	inositol trisphosphate metabolic process
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process