Version 5.4
Homo sapiens Gene: ITPK1
Summary
InnateDB Gene IDBG-17293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPK1
Gene Name inositol-tetrakisphosphate 1-kinase
Synonyms ITRPK1
Species Homo sapiens
Ensembl Gene ENSG00000100605
Encoded Proteins
IDBP-17297
inositol-tetrakisphosphate 1-kinase
IDBP-17299
inositol-tetrakisphosphate 1-kinase
IDBP-601789
inositol-tetrakisphosphate 1-kinase
IDBP-599254
inositol-tetrakisphosphate 1-kinase
IDBP-603064
inositol-tetrakisphosphate 1-kinase
IDBP-598058
inositol-tetrakisphosphate 1-kinase
IDBP-586335
inositol-tetrakisphosphate 1-kinase
IDBP-591586
inositol-tetrakisphosphate 1-kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:92936914-93116320
Strand Reverse strand
Band q32.12
Transcripts
ENST00000267615 ENSP00000267615
ENST00000354313 ENSP00000346272
ENST00000556603 ENSP00000451091
ENST00000555495 ENSP00000451893
ENST00000556954
ENST00000553695
ENST00000554999 ENSP00000451154
ENST00000556185
ENST00000555553 ENSP00000452258
ENST00000553452 ENSP00000452230
ENST00000557309 ENSP00000450421
ENST00000553655
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0047325 inositol tetrakisphosphate 1-kinase activity
GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity
GO:0052825 inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
GO:0052830 inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
GO:0052831 inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
GO:0052835 inositol-3,4,6-trisphosphate 1-kinase activity
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0016310 phosphorylation
GO:0016311 dephosphorylation
GO:0032957 inositol trisphosphate metabolic process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057963
View Gene Order
ENSBTAG00000009845
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_150188
Synthesis of pyrophosphates in the cytosol pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.308122
RefSeq NM_001142593 NM_001142594 NM_014216
HUGO
OMIM
CCDS CCDS45157 CCDS9907
HPRD 03501
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca