InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif5

Summary

InnateDB Protein

IDBP-173167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif5

Protein Name

eukaryotic translation initiation factor 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061616

InnateDB Gene

IDBG-173165 (Eif5)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006413

translational initiation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:95309

InterPro

IPR002735 Translation initiation factor IF2/IF5
IPR003307 W2 domain
IPR016024 Armadillo-type fold
IPR016189 Translation initiation factor IF2/IF5, N-terminal
IPR016190 Translation initiation factor IF2/IF5, zinc-binding

PFAM

PF01873
PF02020

PRINTS

PIRSF

SMART

SM00653
SM00515

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P59325