InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpi1

Summary

InnateDB Protein

IDBP-173257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpi1

Protein Name

glucose phosphate isomerase 1

Synonyms

Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org; Pgi; Phi;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049355

InnateDB Gene

IDBG-173255 (Gpi1)

Protein Structure

UniProt Annotation

Function

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

Subcellular Localization

Cytoplasm. Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004347	glucose-6-phosphate isomerase activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001707	mesoderm formation
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0034101	erythrocyte homeostasis
GO:0042593	glucose homeostasis
GO:0061620	glycolytic process through glucose-6-phosphate