InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gpi1

Summary

InnateDB Gene

IDBG-173255.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpi1

Gene Name

glucose phosphate isomerase 1

Synonyms

Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org; Pgi; Phi

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036427

Encoded Proteins

IDBP-173257

glucose phosphate isomerase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:34202122-34230289

Strand

Reverse strand

Band

Transcripts

ENSMUST00000038027	ENSMUSP00000049355
ENSMUST00000135243
ENSMUST00000126901
ENSMUST00000138773

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004347	glucose-6-phosphate isomerase activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001707	mesoderm formation
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0034101	erythrocyte homeostasis
GO:0042593	glucose homeostasis
GO:0061620	glycolytic process through glucose-6-phosphate