InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mark3

Summary

InnateDB Protein

IDBP-173291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mark3

Protein Name

MAP/microtubule affinity-regulating kinase 3

Synonyms

1600015G02Rik; A430080F22Rik; C-TAK1; Emk2; ETK-1; ETK1; MPK10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074757

InnateDB Gene

IDBG-173285 (Mark3)

Protein Structure

UniProt Annotation

Function

Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468

protein phosphorylation

Cellular Component

GO:0005886

plasma membrane

Protein Structure and Domains

PDB ID

MGI:1341865

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001772 Kinase associated domain 1 (KA1)
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028375 KA1 domain/Ssp2 C-terminal domain

PFAM

PF00069
PF07714
PF02149

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00165
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt