InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dock10

Summary

InnateDB Protein

IDBP-173297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dock10

Protein Name

dedicator of cytokinesis 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077099

InnateDB Gene

IDBG-173295 (Dock10)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0017048	Rho GTPase binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0030334	regulation of cell migration
GO:0032319	regulation of Rho GTPase activity

Cellular Component

GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2146320

InterPro

IPR001849 Pleckstrin homology domain
IPR010703 Dedicator of cytokinesis C-terminal
IPR016024 Armadillo-type fold
IPR021816 Dedicator of cytokinesis C/D, N-terminal

PFAM

PF00169
PF06920
PF11878

PRINTS

PIRSF

SMART

SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite