InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lsm14a

Summary

InnateDB Protein

IDBP-173432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lsm14a

Protein Name

LSM14 homolog A (SCD6, S. cerevisiae)

Synonyms

2700023B17Rik; AA407828; AU017544; Tral;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082723

InnateDB Gene

IDBG-173430 (Lsm14a)

Protein Structure

UniProt Annotation

Function

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=Targeted to stress granules (SGs) in response to cellular stress. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006417	regulation of translation
GO:0007275	multicellular organismal development
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0039529	RIG-I signaling pathway
GO:0051607	defense response to virus
GO:0060340	positive regulation of type I interferon-mediated signaling pathway