InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chl1

Summary

InnateDB Protein

IDBP-173448.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chl1

Protein Name

cell adhesion molecule with homology to L1CAM

Synonyms

A530023M13Rik; AI465420; CALL; LICAM2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063933

InnateDB Gene

IDBG-173444 (Chl1)

Protein Structure

UniProt Annotation

Function

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. {ECO:0000269PubMed:10022583, ECO:0000269PubMed:10103075, ECO:0000269PubMed:12391163, ECO:0000269PubMed:12721290, ECO:0000269PubMed:12812975, ECO:0000269PubMed:14659567, ECO:0000269PubMed:14761956, ECO:0000269PubMed:15504324, ECO:0000269PubMed:16623841}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=Soluble forms produced by cleavage/shedding also exist.Processed neural cell adhesion molecule L1- like protein: Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Expressed in the brain, in the cerebellum and in the spinal cord. Detected in the retina and the optic nerve. Expressed in neurons and glial cells in the central nervous system and by Schwann cells in the peripheral nervous system. {ECO:0000269PubMed:10103075, ECO:0000269PubMed:15504324, ECO:0000269PubMed:8921253}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0007411	axon guidance
GO:0008344	adult locomotory behavior
GO:0031103	axon regeneration
GO:0031175	neuron projection development
GO:0035640	exploration behavior
GO:0043524	negative regulation of neuron apoptotic process
GO:0050890	cognition

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:1098266

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70232